A woman is kidnapped and tossed into a sack in the water. She manages to escape from the sack and survive, but has no memory at all of her past life, not even her name. She keeps picturing a man dressed in all black chasing her. Is it her mind playing tricks? Was it her kidnapper?

Quitters tells the story of the Raymans, a wealthy Jewish family that's falling apart. The son, Clark, is a bright and curious high schooler with a talent for manipulation. As his mother May enters treatment for a pill addiction, and he and his father Roger stop getting along, Clark thinks about running away from home. He just needs to decide where to go.

In a small town south of San Francisco, Sheriff Paul Del Moral (Pepe Serna) is driving home through the fog when he accidentally strikes a pedestrian, a lone Japanese man. However, before an investigation can take place the man disappears from the hospital without a trace. At the same time, Japanese mystery author Aki Akahori (Ayako Fujitani) takes a trip to San Francisco in order to escape the press tour for her latest book--a potboiler in her world famous "Inspector Takabe" series. Feeling lonely and vulnerable, she begins a romantic affair with a mysterious Japanese traveler from Reno (Kazuki Kitamura). Her new lover is charismatic and charming but abruptly disappears from the hotel, leaving behind his suitcase and a trail of questions...